Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC036
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-28 16:02
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl Madopar 250mg 4x1/2 caps Madopar HBS 125mg

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 36, 'TN': 27, 'TP': 6, 'FP': 3}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 26, 'TP': 15, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 18, 'TN': 9, 'TP': 24, 'FP': 21}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 12, 'TN': 9, 'TP': 30, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 3.796
timePerCircleCoV 0.40439
timePerCircleSlope -0.107226
meanError 2.64419
tremorFreq 5.46875
tremorRelPower 26.691
tremorGyroAmpMean 0.0376029
tremorGyroAmpSlope 0.0259182
tremorGyroAmpCoV 0.522916
tremorCoordAmpMean 0.104086
tremorCoordAmpSlope 0.0311676
tremorCoordAmpCoV 0.467437
tremorAccAmpMean 0.0822563
tremorAccAmpSlope 0.0194421
tremorAccAmpCoV 0.456506
tremorPcRelVar 0.750168
tremorPcX 0.463728
tremorPcY -0.885977

Circle Segment 1

Duration 7.2 s, Accuracy Estimate 1.811 (lower is better)

Circle Segment 2

Duration 5.28 s, Accuracy Estimate 2.244 (lower is better)

Circle Segment 3

Duration 5.0 s, Accuracy Estimate 2.674 (lower is better)

Circle Segment 4

Duration 2.72 s, Accuracy Estimate 2.865 (lower is better)

Circle Segment 5

Duration 3.6 s, Accuracy Estimate 2.409 (lower is better)

Circle Segment 6

Duration 2.84 s, Accuracy Estimate 2.999 (lower is better)

Circle Segment 7

Duration 2.92 s, Accuracy Estimate 2.425 (lower is better)

Circle Segment 8

Duration 2.56 s, Accuracy Estimate 2.745 (lower is better)

Circle Segment 9

Duration 2.8 s, Accuracy Estimate 2.737 (lower is better)

Circle Segment 10

Duration 3.04 s, Accuracy Estimate 3.531 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 9.088
timePerSpiralCoV 0.0870644
timePerSpiralSlope -0.0197397
meanError 2.43713
tremorFreq 5.56641
tremorRelPower 18.0753
tremorGyroAmpMean 0.0837874
tremorGyroAmpSlope 0.00364664
tremorGyroAmpCoV 0.348982
tremorCoordAmpMean 0.146824
tremorCoordAmpSlope 0.0017797
tremorCoordAmpCoV 0.292385
tremorAccAmpMean 0.112162
tremorAccAmpSlope 0.00119369
tremorAccAmpCoV 0.242937
tremorPcRelVar 0.605074
tremorPcX -0.382675
tremorPcY 0.923883

Spiral Segment 1

Duration 9.8 s, Accuracy Estimate 2.112 (lower is better)

Spiral Segment 2

Duration 10.04 s, Accuracy Estimate 1.991 (lower is better)

Spiral Segment 3

Duration 9.32 s, Accuracy Estimate 2.284 (lower is better)

Spiral Segment 4

Duration 9.32 s, Accuracy Estimate 2.35 (lower is better)

Spiral Segment 5

Duration 10.28 s, Accuracy Estimate 2.362 (lower is better)

Spiral Segment 6

Duration 8.2 s, Accuracy Estimate 2.708 (lower is better)

Spiral Segment 7

Duration 8.0 s, Accuracy Estimate 2.628 (lower is better)

Spiral Segment 8

Duration 8.48 s, Accuracy Estimate 2.613 (lower is better)

Spiral Segment 9

Duration 8.92 s, Accuracy Estimate 2.716 (lower is better)

Spiral Segment 10

Duration 8.52 s, Accuracy Estimate 2.608 (lower is better)

Elel

eDurationMean 0.317361
eDurationStd 0.0742052
eDurationStdnorm 0.233819
eDurationMedian 0.305
eDurationQuartdelta 0.1075
eDurationQuartdeltanorm 0.352459
eDurationKurt 3.59935
eDurationTrenddiff -0.0825
eDurationTrendratio 0.772414
eWidthMean 3.51
eWidthStd 1.17965
eWidthStdnorm 0.336084
eWidthMedian 3.393
eWidthQuartdelta 0.936
eWidthQuartdeltanorm 0.275862
eWidthKurt 16.6975
eWidthTrenddiff 0.117
eWidthTrendratio 1.03571
eHeightMean 6.58125
eHeightStd 1.63163
eHeightStdnorm 0.247921
eHeightMedian 6.903
eHeightQuartdelta 1.872
eHeightQuartdeltanorm 0.271186
eHeightKurt 3.5207
eHeightTrenddiff -0.234
eHeightTrendratio 0.967213
eAspectMean 0.5576
eAspectStd 0.186798
eAspectStdnorm 0.335004
eAspectMedian 0.516433
eAspectQuartdelta 0.229088
eAspectQuartdeltanorm 0.443597
eAspectKurt 5.58515
eAspectTrenddiff -0.0270833
eAspectTrendratio 0.948617
eSlantMean 0.0102053
eSlantStd 0.248194
eSlantStdnorm 24.3201
eSlantMedian -0.0251311
eSlantQuartdelta 0.214396
eSlantQuartdeltanorm -8.53112
eSlantKurt 5.60403
eSlantTrenddiff 0.0120755
eRtopMean 0.628675
eRtopStd 0.199979
eRtopStdnorm 0.318095
eRtopMedian 0.616796
eRtopQuartdelta 0.296371
eRtopQuartdeltanorm 0.480501
eRtopKurt 1.98514
eRtopTrenddiff 0.188578
eRbotMean 0.662614
eRbotStd 0.280738
eRbotStdnorm 0.423683
eRbotMedian 0.629121
eRbotQuartdelta 0.298112
eRbotQuartdeltanorm 0.473855
eRbotKurt 4.46803
eRbotTrenddiff 0.146474
eRrightMean 0.800208
eRrightStd 0.117426
eRrightStdnorm 0.146745
eRrightMedian 0.809722
eRrightQuartdelta 0.188881
eRrightQuartdeltanorm 0.233266
eRrightKurt 3.18982
eRrightTrenddiff 0.0534251
eRleftMean 0.505137
eRleftStd 0.186267
eRleftStdnorm 0.368746
eRleftMedian 0.486327
eRleftQuartdelta 0.291433
eRleftQuartdeltanorm 0.599253
eRleftKurt 2.20653
eRleftTrenddiff -0.00381981
lDurationMean 0.4574
lDurationStd 0.0827914
lDurationStdnorm 0.181004
lDurationMedian 0.435
lDurationQuartdelta 0.1075
lDurationQuartdeltanorm 0.247126
lDurationKurt 3.09069
lDurationTrenddiff -0.0925
lDurationTrendratio 0.81592
lWidthMean 5.59728
lWidthStd 1.86549
lWidthStdnorm 0.333286
lWidthMedian 5.382
lWidthQuartdelta 2.2815
lWidthQuartdeltanorm 0.423913
lWidthKurt 3.07998
lWidthTrenddiff -2.106
lWidthTrendratio 0.675676
lHeightMean 21.4625
lHeightStd 3.5293
lHeightStdnorm 0.16444
lHeightMedian 21.06
lHeightQuartdelta 2.1645
lHeightQuartdeltanorm 0.102778
lHeightKurt 7.19973
lHeightTrenddiff -1.9305
lHeightTrendratio 0.912
lAspectMean 0.260426
lAspectStd 0.0731334
lAspectStdnorm 0.280823
lAspectMedian 0.252252
lAspectQuartdelta 0.104569
lAspectQuartdeltanorm 0.414542
lAspectKurt 2.73593
lAspectTrenddiff -0.0346719
lAspectTrendratio 0.863748
lSlantMean 0.0621552
lSlantStd 0.0767564
lSlantStdnorm 1.23491
lSlantMedian 0.0628272
lSlantQuartdelta 0.0685851
lSlantQuartdeltanorm 1.09165
lSlantKurt 3.03756
lSlantTrenddiff -0.0217847
lRtopMean 0.850858
lRtopStd 0.153035
lRtopStdnorm 0.17986
lRtopMedian 0.877551
lRtopQuartdelta 0.161627
lRtopQuartdeltanorm 0.184179
lRtopKurt 7.78155
lRtopTrenddiff -0.0262965
lRbotMean 0.629941
lRbotStd 0.232756
lRbotStdnorm 0.369489
lRbotMedian 0.6
lRbotQuartdelta 0.274957
lRbotQuartdeltanorm 0.458261
lRbotKurt 4.25651
lRbotTrenddiff 0.0514123
lRrightMean 0.919492
lRrightStd 0.103134
lRrightStdnorm 0.112164
lRrightMedian 0.946809
lRrightQuartdelta 0.104862
lRrightQuartdeltanorm 0.110753
lRrightKurt 9.11166
lRrightTrenddiff -0.0527793
lRleftMean 0.317288
lRleftStd 0.124745
lRleftStdnorm 0.393158
lRleftMedian 0.278075
lRleftQuartdelta 0.174608
lRleftQuartdeltanorm 0.627918
lRleftKurt 2.55941
lRleftTrenddiff -0.0641947

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.619868
sumTouchScores 15.4967
meanMovementTime 0.770417
numTouches 25
undershootPercentage 4
overshootPercentage 40

FITTS Long Modified

meanTouchScore 0.907478
sumTouchScores 18.1496
meanMovementTime 0.936842
numTouches 20
undershootPercentage 5
overshootPercentage 15

ZigZag

numZigzags 5
timePerZigzagMean 8.744
timePerZigzagCoV 0.197889
timePerZigzagSlope -0.122598
meanError 3.66817
tremorFreq 6.25
tremorRelPower 21.0543
tremorGyroAmpMean 0.0509755
tremorGyroAmpSlope 0.014241
tremorGyroAmpCoV 0.293988
tremorCoordAmpMean 0.124065
tremorCoordAmpSlope 0.0140017
tremorCoordAmpCoV 0.311854
tremorAccAmpMean 0.0973266
tremorAccAmpSlope 0.00774362
tremorAccAmpCoV 0.139543
tremorPcRelVar 0.879949
tremorPcX 0.0490115
tremorPcY -0.998798

ZigZag Segment 1

Duration 10.68 s, Accuracy Estimate 3.557 (lower is better)

ZigZag Segment 2

Duration 10.12 s, Accuracy Estimate 3.113 (lower is better)

ZigZag Segment 3

Duration 8.96 s, Accuracy Estimate 3.348 (lower is better)

ZigZag Segment 4

Duration 7.16 s, Accuracy Estimate 4.176 (lower is better)

ZigZag Segment 5

Duration 6.8 s, Accuracy Estimate 4.147 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 7.936
timePerZigzagCoV 0.195035
timePerZigzagSlope -0.119456
zigzagHeightMean 83.2159
zigzagHeightCoV 0.0679352
zigzagHeightSlope 0.0296565
meanError 0.0422421
tremorFreq 6.05469
tremorRelPower 23.6993
tremorGyroAmpMean 0.0926566
tremorGyroAmpSlope 0.0341387
tremorGyroAmpCoV 0.276879
tremorCoordAmpMean 0.213152
tremorCoordAmpSlope 0.0290875
tremorCoordAmpCoV 0.339256
tremorAccAmpMean 0.10437
tremorAccAmpSlope 0.0264009
tremorAccAmpCoV 0.273835
tremorPcRelVar 0.919171
tremorPcX 0.0272638
tremorPcY -0.999628

ZigZag Offset Segment 1

Duration 10.12 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 2

Duration 8.92 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 3

Duration 7.28 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 4

Duration 7.04 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 5

Duration 6.32 s, Accuracy Estimate 0.063 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.64}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.9115688336663872}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.54245800839316}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4087734603660057}